Biological DNA Sensor
The Impact of Nucleic Acids on Diseases and Vaccinology

 

 by :

 Ken J. Ishii, Choon Kit Tang (Edit)

 Press :

 Academic Press

 Year :

 2014

 Binding :

 Hardback

 ISBN (13) :

 9780124047327

 ISBN (10) :

 0124047327

 Pages :

 352

 Size :

 16 x 24

 Price :

 $ 149.95

 

 

 
The realization of the immunogenic properties of double stranded DNA and its implications in disease and vaccinology

Overview

Key Features

  • Multi-authored by a distinguished panel of world-class experts
  • Ideal source of information for those wanting to learn about DNA sensing
  • Provides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them

Description

Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines.

Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics.

Readership

Students, scientists and practitioners in innate immunology, autoimmune diseases and vaccinology 

Contents


1. Route to discovering the immunogenic properties of DNA from TLR9 to cytosolic         DNA sensors
             Choon Kit Tang, Cevayir Coban, Shizuo Akira, Ken J Ishii

2. The PYHIN family of molecules and their functions sensing dsDNA
             Sivapriya Kailasan Vanaja, Vijay A. K. Rathinam, Katherine A. Fitzgerald

3. The central role of STING-TBK1 in the DNA sensing pathway
             
Glen Barber    

4. Regulation of intracellular dsDNA-induced innate immune responses by         autophagy-related proteins
    
Running title: Autophagy and dsDNA-induced innate immunity
             Tatsuya Saitoh

5. Host DNA Induced Inflammation and Autoimmune Diseases
             Surya Pandey, Taro Kawai

6. Systemic lupus erythematosus and the DNA sensing pathway
             Ann Marshak-Rothstein    

7. Bacterial infections and the DNA sensing pathway
             Jan Naujoks, Bastian Opitz

8. Viral infections and the DNA sensing pathway: lessons from herpesviruses and       beyond
            Soren R. Paludan, Andrew G. Bowie

9. Cancer Pathogenesis and DNA sensing
            Shen Y.J., Lam A.R., Ho S.S.W., Koo C.X., Le Bert N., Gasser S.

10. Atherosclerosis and Aging and DNA sensing
            Moshe Arditi

11. DNA Vaccines: Does it Target the Double Stranded-DNA Sensing Pathway?
           Cevayir Coban, Miyuki Tozuka, Nao Jounai, Kouji Kobiyama, Fumihiko            Takeshita, Choon Kit Tang, Ken J. Ishii

12. Adjuvants targeting the DNA sensing pathways ? Alum based adjuvants
           Christophe J. Desmet

13. Adjuvants Targeting the DNA Sensing Pathways? Cyclic-di-GMP and Other         Cyclic-di-Nucleotides
           Rebecca Schmidt, Laurel L. Lenz


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